Psychology
Hamed Maleki; Fatemeh Tabatabaee; Mosayeb Bagherinik; Sheila Laka; Mojgan Mohajeri Iravani; Mohammad Javad Namazi
Volume 28, Issue 6 , January and February 2022, , Pages 885-896
Abstract
Background: The coronavirus pandemic has created the most fatal health crisis in humanity in the recent century. The present study was designed to investigate the relationship between employees' spirituality and organizational vitality in the outcome of the health carers' work in Hajar hospital, an army ...
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Background: The coronavirus pandemic has created the most fatal health crisis in humanity in the recent century. The present study was designed to investigate the relationship between employees' spirituality and organizational vitality in the outcome of the health carers' work in Hajar hospital, an army hospital in Tehran, during the first year of the COVID-19 pandemic. The main purpose was to determine any significant relationships between staff spirituality and organizational vitality.Methods: This descriptive survey study was performed from March 2019 to February 2020. Seventy-one employees were recruited as the sample size using the Morgan table. The characteristic of the components of employees' spirituality were examined by performing Kingerski and Skrypnek questionnaires. All variables of the organizational vitality were determined using Rojelf model and a researcher-made questionnaire which was approved by the relevant experts. To analyze the data for determination the relationship among indicators, the structural equation model was exercised using LISREL software.Results: Most of the cases were between 21 and 39 years old. The results showed that there were significant relationships between all examined characteristics of the employees' spirituality and organizational vitality.Conclusion: The results confirmed that there were significant relationships between spiritual desire, spiritual connection, sense of unity, mystical experience and the organizational vitality components including positive thinking, organizational learning, organizational participation, organizational openness, meaningful life, and interest. Accordingly, determining the effects of interactions among those values in their reciprocal promotions are deserved to be seriously studied to achieve an advanced and successful COVID-19 disease management.
Microbiology
Behnaz Jalalizadegan; Fatemeh Ghaffarifar; Soudabeh Fallah; Taher Elmi; Mohammad Javad Namazi; Fatemeh Vafa Shoar; Fatemeh Tabatabaee
Volume 26, Issue 4 , November and December 2019, , Pages 515-525
Abstract
Background: Toxoplasma gondii is an obligatory intracellular parasite causes toxoplasmosis. The parasite has two forms, noninvasive bradizoites and invasive tachizoites. The present study, for the first time, aimed to evaluate the effect of vitamins C and E on nitric oxide (NO) elevation to promote killing ...
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Background: Toxoplasma gondii is an obligatory intracellular parasite causes toxoplasmosis. The parasite has two forms, noninvasive bradizoites and invasive tachizoites. The present study, for the first time, aimed to evaluate the effect of vitamins C and E on nitric oxide (NO) elevation to promote killing invasive tachizoites by macrophages in susceptible BALB/c mice.Materials and Methods: Seventy BALB/c mice were recruited and randomly divided into fourteen groups of five (n=5). Control groups: one group left intact. Two groups were given saline or methanol. Two groups were infected with 104 or 5×104 parasites. The other groups were administrated only vitamin C, E, or both. The rest of sample and control groups were infected with either 104 or 5×104 tachizoites and supplemented with 100 µl vitamin E every other day, or 200 µl of vitamin C daily. Vitamins were intraperitoneally administered up to five days. On sixth day mice were intraperitoneally infected with tachyzoites. The blood samples were taken three days post infection, serum collected and stored at - 20 Cº until examinations. The peritoneal macrophages were isolated for counting phagocytised tachyzoites and nitric oxide assays.Results: Tachyzoites were significantly decreased after vitamin C & E administration in the infected mice compared to the controls. In mice supplemented vitamins NO levels were significantly higher compared to controls. Conclusion: Our findings showed that administration of vitamin C, E or both significantly enhanced killing invasive parasites through NO elevation produced by activated macrophages and may have therefore, complementary therapeutic effects.
Somayyeh Zarrati; Sobhan Fayezi; Hamid Sadighiyan; AbbasAli Imani Foladi; Mehdi Mahdavi; Reza Falak; Narges Tehrani; Fatemeh Tabatabaee
Volume 21, Issue 6 , January and February 2015, , Pages 1182-1193
Abstract
Background: Leishmaniasis is a major infectious disease caused by protozoan parasites of the genusLeishmania.Despite of many efforts have been madeno effective vaccineagainst Leishmania infectionhas been approved yet.The major advantage of DNAvaccine isto induce the expression of antigens, which are ...
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Background: Leishmaniasis is a major infectious disease caused by protozoan parasites of the genusLeishmania.Despite of many efforts have been madeno effective vaccineagainst Leishmania infectionhas been approved yet.The major advantage of DNAvaccine isto induce the expression of antigens, which are unaltered in their protein structure and antigenicity. In this study, in order to increase immunity, thecandidate DNA vaccine has been supplemented with nano-adjuvant and its immunogenicity was tested on BALB/c rats.
Materials and Methods: Considering other studies that have demonstratedLeishmania TSA protein is antigenic in both murine and human systems, in this study a new nanovaccinecontaining TSA recombinant plasmid and poly(methylmethacrylate) (PMMA) nanoparticles (as an adjuvant) was designed. After three intramuscular injection of nanovaccine (100 µg),the recombinant TSA protein(20 µg) was injected subcutaneously.3 weeks later,animal were infected by Leishmania major.Finally lymphocyte proliferation and cellular immune responses (IFN-γ,IL-4 prodution) were evaluated byusinigBrdu and ELISA methods.
Results: Theresultsof this study showed that the new nanovaccine was capable of inducing both cytokines secretion,but predominant Th1 immune response characterized by IFN-γ production compared to control groups.
Conclusion: Results revealed that, current candidate nanovaccine has potency for future studies to prepare vaccine against Leishmania.
Fatemeh Tabtabee; Fatemeh Maleki; Zahra Abareh Dory Tafreshi; Narges Shahmohammadi; Majid Pirestani
Volume 21, Issue 5 , September and October 2014, , Pages 885-893
Abstract
Background and purpose:Microsporidia infections occurvirtually in all in vertebrate and vertebrate hosts,in cluding humans. The this study is aimed atcomparison of distribution of microsporidiosis in various samples of Iranian immunocompromised patients and healthy individuals by molecular methods. ...
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Background and purpose:Microsporidia infections occurvirtually in all in vertebrate and vertebrate hosts,in cluding humans. The this study is aimed atcomparison of distribution of microsporidiosis in various samples of Iranian immunocompromised patients and healthy individuals by molecular methods.
Materials and Methods: Inthiscase - control study, 258stool, blood, bronchoalveolar lavage (BAL) and urine sampleswere obtained fromimmunocompromisedpatients (bone marrowtransplant, kidney transplant and respiratory complications) referred to Masih Daneshvari and Shariati Hospitalduring 2010-2011.
After recording clinical data, DNA extraction was performed on all samples. To identifyhuman related microsporidiosis (Encephalitozoon spp. And Enterocytozoon spp.), polymerase chain reactionwas performedusingspecific primers andmultiplex-PCR on allsamples.
Results: Overall, the prevalence of microsporidiosis in immunocompromised patients were 4.3 and 3.9 percent in cases and control group, respectively.Incidence of microsporidiosis in patients undergoing bone marrow transplantation (5 isolates from 70 samples) was 7.1%, in patients with respiratory complications (4 isolates from 150 samples) 2.7 percent and patients undergoing renal transplantation (2 isolates from 38 samples) 5.3 percent. In the case group, most cases of infection occurred among men at the age of40-60 years. In bronchoalveolar lavage samples 3 isolates of Encephalitozoon (2%) and one isolate of Entrocytozoon (0.7%), were identified, respectively. In cancer patients undergoing bone marrow transplantation 4 isolates of Encephalitozoon (5.7%), 1 isolate of Enterocytozoon (1.4%) and in patients with renal transplants 2 isolates of Enterocytozoon (5.3%)were detected. 4 isolates of Enterocytozoon (2.2%) and 3 isolates of Encephalitozoon (1.7%) were identified in the control group that most infections occurred among menat the age of30-45years.
Conclusion:The most cases of human microsporidiosis are associated with human immunodeficiency virus infection or other states of immunosuppression, particularly in organ transplant recipients; The obtained results confirm this claim.
Somayyeh Tarihi; Ramtin Hadighi; MohammadJavad Namazi; Fatemeh Tabatabaee; AhmadReza Memar; Lame Akhlaghi; Afshin Davari
Volume 20, Issue 1 , March and April 2013, , Pages 101-108
Abstract
Background: Although all the advances of medical science has come to achieve, parasitic infections including intestinal parasites in many countries especially in developing countries, is a health problem; according to the annual fees paid by that the World Health Organization and governments to eliminate, ...
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Background: Although all the advances of medical science has come to achieve, parasitic infections including intestinal parasites in many countries especially in developing countries, is a health problem; according to the annual fees paid by that the World Health Organization and governments to eliminate, prevent and treat them, their existence is still visible. In this study the prevalence of intestinal parasite in mental disability community in Ardabil city will be studied. Materials and methods: This descriptive cross-sectional study with was design to detect the prevalence of intestinal parasites on the 216 cases of mental disability under the Social Welfare Organization in Ardabil city, with methods of direct smear, formalin ether concentration method and Modified ziehl-neelsen staining. Results: From 216 patients 95 samples (44%) were infected with at least one parasite including Blastocystis hominis 41 cases (19%), Entamoeba coli cyst 25 cases (11.6%), Giardia cyst 18 cases (8.3%), Trichuris trichura egg 2 cases (0.9%) and contemporary infection with two parasite Entamoeba coli / Blastocystis hominis cysts and Entamoeba coli / Iodamoeba butschili cysts 4 (1.9%) and 3 (1.4%) cases respectively. In 0.5% of cases we found Entamoeba coli cyst with 4 nuclei cysts.
Conclusion: According to the results, levels of intestinal parasitic infections in mental disability community in the Ardabil city in compare to other communities was higher that need to pay more attention of the authorities.